:root{--bg: #050706;--panel: #0e1412;--panel-2: #121a17;--canvas: #030404;--line: #1f2a25;--line-2: #2c3a33;--text: #e6ece8;--text-strong: #f4f7f5;--muted: #a7b2ac;--faint: #8f9b94;--accent: #d9f26b;--accent-ink: #0e1412;--accent-soft: #182219;--accent-line: #4f6230;--danger: #ff8a7a;--serif: "Fraunces", Georgia, "Times New Roman", serif;--sans: "Inter", system-ui, -apple-system, "Segoe UI", sans-serif;color-scheme:dark}*{box-sizing:border-box}html,body,#root{height:100%}body{margin:0;background:var(--bg);color:var(--text);font-family:var(--sans);font-size:13px;-webkit-font-smoothing:antialiased}button,input,select{font:inherit;color:inherit}button{cursor:pointer}button:disabled{cursor:not-allowed;opacity:.45}:focus-visible{outline:2px solid var(--accent);outline-offset:2px}.app{display:grid;grid-template-columns:320px minmax(0,1fr);height:100vh}.sidebar{background:var(--panel);border-right:1px solid var(--line);overflow-y:auto;padding:26px 24px 24px;display:flex;flex-direction:column;gap:18px}.brand{display:flex;flex-direction:column;gap:8px;padding-bottom:18px;border-bottom:1px solid var(--line)}.eyebrow{font-size:11px;font-weight:700;letter-spacing:.12em;text-transform:uppercase;color:var(--accent)}.brand h1{margin:0;font-family:var(--serif);font-weight:700;font-size:32px;line-height:1.05;color:var(--text-strong);letter-spacing:-.01em}.brand p{margin:0;font-size:13px;line-height:1.55;color:var(--muted)}.sidebar section{display:flex;flex-direction:column;gap:8px;padding-bottom:18px;border-bottom:1px solid var(--line)}.sidebar h2{margin:0 0 2px;font-size:11px;font-weight:700;letter-spacing:.12em;text-transform:uppercase;color:var(--faint)}.eyebrow-label{display:block;margin-top:4px;font-size:10px;font-weight:600;letter-spacing:.08em;text-transform:uppercase;color:var(--faint)}.atlas-list{display:flex;flex-direction:column;gap:6px}.atlas{display:flex;align-items:center;gap:14px;width:100%;min-height:60px;padding:10px 12px;text-align:left;border-radius:10px;border:1px solid transparent;background:transparent}.atlas:hover:not(:disabled){background:var(--panel-2)}.atlas.on{background:var(--accent-soft);border-color:var(--accent-line)}.glyph{flex:0 0 auto;width:34px;height:34px;border-radius:50%;background:var(--accent);color:var(--accent-ink);display:grid;place-items:center;font-family:var(--serif);font-style:italic;font-weight:700;font-size:17px}.atlas-text{display:flex;flex-direction:column;gap:1px}.atlas-name{font-size:14px;font-weight:700;font-style:italic;color:var(--text-strong)}.atlas-sub{font-size:11px;color:var(--faint)}.atlas-stage{font-size:11px;color:var(--muted)}.segmented{display:grid;gap:4px;padding:4px;border:1px solid var(--line-2);border-radius:10px}.segmented button{min-height:34px;border:0;border-radius:6px;background:transparent;color:var(--muted);font-size:12px;font-weight:600;padding:0 8px}.segmented button:hover:not(:disabled):not(.on){color:var(--text-strong);background:var(--panel-2)}.segmented button.on{background:var(--accent);color:var(--accent-ink)}select,input[type=text]{width:100%;min-height:38px;padding:0 12px;border-radius:8px;border:1px solid var(--line-2);background:#0a0f0d;color:var(--text-strong);font-size:13px}select{-webkit-appearance:none;-moz-appearance:none;appearance:none;background-image:linear-gradient(45deg,transparent 50%,var(--faint) 50%),linear-gradient(135deg,var(--faint) 50%,transparent 50%);background-position:calc(100% - 18px) 16px,calc(100% - 13px) 16px;background-size:5px 5px;background-repeat:no-repeat;padding-right:34px}input[type=range]{width:100%;accent-color:var(--accent)}.gene-search{position:relative}.gene-list{position:absolute;z-index:20;left:0;right:0;top:calc(100% + 4px);margin:0;padding:4px;list-style:none;background:#0a0f0d;border:1px solid var(--line-2);border-radius:8px;max-height:300px;overflow-y:auto;box-shadow:0 12px 30px #00000080}.gene-list li{display:flex;justify-content:space-between;gap:10px;padding:7px 10px;border-radius:6px;cursor:pointer}.gene-list li.active{background:var(--accent-soft)}.gene-name{font-style:italic;font-weight:600;color:var(--text-strong)}.gene-meta{font-size:11px;color:var(--faint)}.gene-empty{color:var(--faint);cursor:default!important}.chips{display:flex;flex-wrap:wrap;gap:6px}.chip{display:inline-flex;align-items:center;gap:6px;padding:3px 4px 3px 10px;border:1px solid var(--line-2);border-radius:999px;background:var(--panel-2);font-size:12px}.chip i{font-weight:600;color:var(--text-strong)}.chip-dot{width:9px;height:9px;border-radius:50%}.chip button{width:24px;height:24px;border-radius:50%;border:0;background:transparent;color:var(--faint);display:grid;place-items:center}.chip button:hover{color:var(--text-strong);background:var(--line-2)}.help{margin:2px 0 0;padding:10px 12px;border-radius:8px;background:var(--panel-2);border:1px solid var(--line-2);font-size:12px;line-height:1.55;color:#c4cdc8}.data-use{margin:0;font-size:11px;line-height:1.5;color:var(--faint)}.main{display:flex;flex-direction:column;min-width:0;min-height:0;background:var(--canvas)}.topbar{display:flex;flex-wrap:wrap;justify-content:space-between;align-items:center;gap:16px;padding:16px 24px;background:#0b100e;border-bottom:1px solid var(--line)}.title-block{display:flex;flex-direction:column;gap:6px;min-width:0;flex:1 1 300px}.title{font-family:var(--serif);font-size:21px;font-weight:600;color:var(--text-strong)}.pill{align-self:flex-start;display:inline-flex;align-items:center;gap:7px;padding:2px 10px;border:1px solid #3a4a40;border-radius:999px;font-size:10px;font-weight:700;letter-spacing:.06em;color:#c4cdc8}.pill .dot,.statusbar .dot{width:7px;height:7px;border-radius:50%;background:#e69f00;display:inline-block}.top-right{display:flex;flex-wrap:wrap;align-items:center;justify-content:flex-end;gap:22px}.stats{display:flex;gap:18px;margin:0}.stats div{display:flex;flex-direction:column-reverse}.stats dt{font-size:10px;letter-spacing:.08em;text-transform:uppercase;color:var(--faint)}.stats dd{margin:0;font-size:13px;font-weight:700;color:var(--text-strong);font-variant-numeric:tabular-nums}.actions{display:flex;flex-wrap:wrap;gap:8px}.actions button{min-height:34px;padding:0 11px;border-radius:7px;border:1px solid var(--line-2);background:var(--panel-2);font-size:11px;color:var(--text)}.actions button:hover:not(:disabled){border-color:var(--accent-line);color:var(--text-strong)}.canvas{position:relative;flex:1 1 auto;min-height:420px;background:var(--canvas)}.canvas.light{background:#fff}.plot{position:absolute;top:0;right:0;bottom:0;left:0}.notice{position:absolute;top:0;right:0;bottom:0;left:0;display:grid;place-items:center;padding:24px;text-align:center;color:var(--muted);line-height:1.6;max-width:560px;margin:auto}.canvas.light .notice{color:#5f6b65}.notice.error{color:var(--danger)}.spinner{position:absolute;top:18px;left:18px;width:22px;height:22px;border-radius:50%;border:2px solid var(--line-2);border-top-color:var(--accent);animation:spin .8s linear infinite}@keyframes spin{to{transform:rotate(360deg)}}.statusbar{display:flex;flex-wrap:wrap;justify-content:space-between;gap:10px;padding:9px 24px;background:#0b100e;border-top:1px solid var(--line);font-size:11px;color:var(--muted)}.statusbar>span:first-child{display:inline-flex;align-items:center;gap:8px}.statusbar .dot{background:var(--accent)}.statusbar .dot.err{background:var(--danger)}.muted{color:var(--faint)}@media (max-width: 900px){.app{grid-template-columns:1fr;height:auto}.sidebar{border-right:0;border-bottom:1px solid var(--line);padding:24px 16px}.topbar,.statusbar{padding-left:16px;padding-right:16px}.canvas{min-height:70vh}}